Name: Cheesy Cajun Beef Spaghetti in Creamy Three-Cheese Parmesan Sauce
Prep time: 10 min
Cook time: 25 min
Total time: 35 min
Cuisine: American
Ingredients: 1 lb ground beef; 2-3 tsp Cajun seasoning (adjust to taste); 12 oz spaghetti noodles; 1 cup heavy cream; 4 oz cream cheese; 1 cup shredded mozzarella cheese; 1/2 cup freshly grated Parmesan cheese; 2 cloves garlic, minced; 2 tbsp butter; Salt and pepper to taste; Fresh parsley, chopped (for garnish, optional)

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This Cheesy Cajun Beef Spaghetti is a deliciously bold twist on classic comfort food. I mix tender spaghetti noodles with seasoned Cajun ground beef and smother everything in a rich, creamy three-cheese Parmesan sauce. It’s a perfect fusion of spicy, cheesy, and hearty that satisfies every time. Cheesy Cajun Beef Spaghetti in Creamy Three-Cheese Parmesan Sauce

Why You’ll Love This Recipe

I love this recipe because it blends the spicy kick of Cajun seasoning with the rich creaminess of a three-cheese sauce, creating an unforgettable meal. It’s hearty, filling, and comes together quickly enough for a weeknight dinner but feels indulgent enough for a special occasion. The flavors are bold, and the textures are luxuriously creamy and cheesy with just the right amount of heat.

Ingredients

(Here’s a tip: Check out the full list of ingredients and measurements in the recipe card below.)

Ground beef
Cajun seasoning
Spaghetti noodles
Heavy cream
Cream cheese
Shredded mozzarella cheese
Freshly grated Parmesan cheese
Garlic
Butter
Salt and pepper
Fresh parsley (for garnish, optional)

Directions

I start by cooking the spaghetti noodles according to package directions, then draining and setting them aside.
In a large skillet, I cook the ground beef over medium heat until it’s browned and cooked through. I drain any excess fat.
I add Cajun seasoning to the beef and stir well, letting the spices infuse for a minute or two.
In a separate saucepan, I melt butter and sauté garlic until fragrant. Then I add heavy cream and bring it to a gentle simmer.
I stir in cream cheese until fully melted and smooth.
Next, I add mozzarella and Parmesan cheese, whisking until the sauce becomes thick, creamy, and cheesy.
I combine the cooked spaghetti, Cajun beef, and cheese sauce in a large pot or pan, tossing to coat everything evenly.
I let it simmer for a couple of minutes to meld all the flavors, then I serve hot, garnished with fresh parsley if desired.

Servings and timing

This recipe makes about 4 to 6 servings and takes roughly 30 to 35 minutes from start to finish, including prep and cooking time.

Variations

Sometimes I swap the ground beef for ground turkey or sausage for a slightly different flavor profile. I also like adding bell peppers or mushrooms to sneak in more veggies. If I want to up the spice level, I toss in a pinch of cayenne or crushed red pepper flakes. And for a different cheesy twist, I experiment with gouda or pepper jack instead of mozzarella.

Storage/Reheating

I store leftovers in an airtight container in the fridge for up to 4 days. When reheating, I prefer using the stovetop over low heat, adding a splash of milk or cream to bring back the creamy texture. It also reheats well in the microwave, but I stir halfway through to ensure even heating.

FAQs

How spicy is this dish?

That depends on the Cajun seasoning used. I usually go for a medium heat, but the spice level can be adjusted to taste by using more or less seasoning.

Can I use a different type of pasta?

Absolutely. While I prefer spaghetti, I’ve also made this with penne, fettuccine, and even rotini. Just use what’s on hand or what I feel like.

Can I make this dish ahead of time?

Yes, I often prepare the sauce and beef mixture ahead and store it separately. When ready to eat, I cook the pasta fresh and combine everything before serving.

Is it possible to make this dish vegetarian?

Sure. I swap the ground beef with plant-based crumbles or sautéed mushrooms and zucchini for a delicious vegetarian version.

What can I use if I don’t have cream cheese?

If I’m out of cream cheese, I use mascarpone or a bit of sour cream to still get that creamy, tangy texture in the sauce.

Conclusion

Cheesy Cajun Beef Spaghetti in Creamy Three-Cheese Parmesan Sauce is one of my go-to comfort meals when I want something flavorful, hearty, and fast. The combination of spice and creaminess is just irresistible. It’s an easy way to elevate a weeknight dinner into something truly satisfying and special.